This report discusses the challenges that confront Plan and other child-focused organisations as they seek to assist those children whose rights are most violated and who are living in some of the poorest and most difficult situations in the world. Organisations have mainly worked with these children according to different categories, such as street children, children in conflict with the law and children in the worst forms of child labour. However, many children have multiple problems and belong to more than one category or move between categories over time. Many of the root causes and factors that impact on the lives of these children are similar. There is therefore the need to develop a more holistic approach, particularly in terms of prevention. This report proposes a framework that can help staff think about working with these groups of children from an integrated child centred and rights based development perspective.